Friday, May 21, 2010

Harper's Illustrated Biochemistry

Extensively revised and updated, this authoritative biochemistry text is known worldwide for its comprehensive and up-to-date coverage.

Extensively illustrated and user-friendly, the text offers examples pf how knowledge of biochemistry is essential for understanding the molecular basis of health and disease.

The 26th edition also features expanded content on results of the Human Genome Project. Perfect as both text and USMLE review. Extensively revised and updated, this authoritative biochemistry text is known worldwide for its comprehensive and up-to-date coverage.

Extensively illustrated and user-friendly, the text offers examples of how knowledge of biochemistry is essential for understanding the molecular basis of health and disease.

The 26th edition also features expanded content on results of the Human Genome Project. Perfect as both text and USMLE review.

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Biochemistry Garrett and Grisham


Intended for the one (or) two term introductory biochemistry course taught at the junior/senior level, this beautifully and consistently illustrated text gives science majors the most current presentation of biochemistry available.

Written by a chemist and a biologist, the book presents biochemistry from balanced perspectives.Undergraduate biochemistry at my school is taught by the biochemistry department (not surprising).

However, as a result, we have all sorts of people taking the course from prospective chemists (me) to premeds and general bio sci majors. So the dept. uses this book and it's probably the best compromise out there.

Voet and Voet would be perfect if the course was taught exclusively for chemists, Stryer if the course was loaded up with premeds (horrifying thought, I know :) ) But Garrett and Grisham have managed to write a rather well balanced text (one is in UVA's bio dept., the other UVA's chem dept) with plenty of both chemical insight and medical relevance.

Based on (I'm sure) similar experiences they've had teaching biochem to a mixed audience, and knowing that most undergrad biochem courses tend to be taught to similar groups of students nationwide, this is the best book for a case like that.

(However, I'm getting Voet and Voet as a reference for me personally one of these days.)

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Text Books of Lehninger Principles of Biochemistry is one of the good book

The Lehninger text has a long history, but given that biochemical knowledge doubles every 5 years or so, it matters what a text offers now, not in the past. The writing is simple, direct, engaging, not too easy but neither too esoteric.

The principles (as the title suggests) and the unity in diversity are emphasized, so that the student understands biochemical principles not merely facts, acronyms, pathways.

The graphics are very professional. They are comparable to any review article in hot journals such as Nature, Science, Cell, etc. The rendering of protein surfaces, and the different angles through which a structure is seen is outstanding (a good example is the section on the ribosomes).

The structures have been rendered from the PDB (protein data bank) coordinates. Most are rendered in the ribbon representation, but in many cases the surface is rendered in grey, depending on the level of detail.

Contrast this with the 3rd edition of Voet: the authors have not bothered to re-render their graphics, most are identical to the 1995 edition, a time when people only cared if you could generate a structure.

Voet's graphics are not done uniformly; the backgrounds can be white, Grey, black, some structures are taken directly from the original literature and vary widely in the format and rendering. It is not enough that Voet updated the text on biochemical developments from 1995-2004.

The Lehninger pages on the most important protein folds, for example, are very helpful in giving the student a feel for the fold, the domain composition, the size, and names of model proteins one is expected to encounter over and again in the research literature. The text contains brief solutions to all the end-of-chapter problems


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